Arnaud FERRY

Contacts

Tél : 06 85 51 27 13

Email : arnaud.ferry@parisdescartes.fr

Adresse professionnelle : UFR STAPS, 1 rue Lacretelle, 75015 Paris

Thèmes de recherche

Physiologie et physiopathologie du muscle strié squelettique et physiologie de l’exercice.

Parcours

a) Diplômes

  • D.E.U.G., Licence et Maîtrise Sciences et Techniques des Activités Physiques et Sportives (S.T.A.P.S.), Université Bordeaux II (1981-1984).
  • D.E.A. en Sciences de la Vie et de la Santé/S.T.A.P.S., Université René Descartes (1985), “Les facteurs de la performance motrice”.
  • Thèse (nouveau régime) en Sciences de la Vie et de la Santé/S.T.A.P.S., Université René Descartes (1990), “Les facteurs de la performance motrice”.  Titre de la thèse: « Les immunomodulations liées à l’exercice musculaire. Etude des leucocytes humains et des cellules mononucléaires chez le rat »
  • Diplôme d’Immunologie Générale et d’Immunotechnologies, Institut Pasteur de Paris (1991),
  • Habilitation à Diriger des Recherches en Sciences de la Vie et de la Santé/S.T.A.P.S., Université René Descartes (1991) : « Effet de l’exercice musculaire sur le système immunitaire ».

b) Fonction :

Boursier du Comité régional olympique sportif d’Ile de France (1986 et 1987),

  • Allocataire d’enseignement et de recherche (1988-1989 et 1989-1990, UFRSTAPS Université Paris X),
  • Boursier de l’Association française contre les myopathies (1990 et 1991),
  • Professeur des Universités, 74ème section du C.N.U (STAPS), Université René Descartes (1992-).

Publications

Klein AF, Varela MA, Arandel L, Holland A, Naouar N, Arzumanov A, Seoane D, Revillod L, Bassez G, Ferry A, Jauvin D, Gourdon G, Puymirat J, Gait MJ, Furling D, Wood MJA. Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice. J Clin Invest. 2019 Sep 3. pii: 128205. Impact factor: 12.28.

Lu-Nguyen N, Ferry A, Schnell FJ, Hanson GJ, Popplewell L, Dickson G, Malerba A. Functional muscle recovery following dystrophin and myostatin exon splice modulation in aged mdx mice. Hum Mol Genet. 2019 Jun 10. Impact factor: 4.90.

Hovhannisyan Y, Melikyan G, Mougenot N, Gao-Li J, Friguet B, Paulin D, Li Z, Ferry A, Agbulut O. Effects of the selective inhibition of proteasome caspase-like activity by CLi a derivative of nor-cerpegin in dystrophic mdx mice. PLoS One. 2019 Apr 23;14(4):e0215821. Impact factor: 1.95.

Deloux R, Tannous C, Ferry A, Li Z, Mericskay M. Aged Nicotinamide Riboside Kinase 2 Deficient Mice Present an Altered Response to Endurance Exercise Training. Front Physiol. 2018 Sep 19;9:1290. Impact factor : 4.13.

Clement Delacroix, Janek Hyzewicz, Megane Lemaitre, Bertrand Friguet, Zhenlin Li, Arnaud Klein, Denis Furling, Onnik Agbulut, Arnaud Ferry. Improvement of dystrophic muscle fragility by short-term voluntary exercise through activation of calcineurin pathway in Mdx mice. Am J Pathol. 2018 Nov;188(11):2662-2673. Impact factor =4.057

Trochet D, Prudhon B, Beuvin M, Peccate C, Lorain S, Julien L, Benkhelifa-Ziyyat S, Rabai A, Mamchaoui K, Ferry A, Laporte J, Guicheney P, Vassilopoulos S, Bitoun M. Allele-specific silencing therapy for Dynamin 2-related dominant centronuclear myopathy. EMBO Mol Med. 2018 Feb;10(2):239-253. Impact factor = 9.24.

Deloux R, Vitiello D, Mougenot N, Noirez P, Li Z, Mericskay M, Ferry A, Agbulut O. Voluntary Exercise Improves Cardiac Function and Prevents Cardiac Remodeling in a Mouse Model of Dilated Cardiomyopathy. Front Physiol. 2017 Nov 15;8:899. Impact factor : 4.13.

Biferi MG, Cohen-Tannoudji M, Cappelletto A, Giroux B, Roda M, Astord S, Marais T, Bos C, Voit T, Ferry A, Barkats M. A New AAV10-U7-Mediated Gene Therapy Prolongs Survival and Restores Function in an ALS Mouse Model. Mol Ther. 2017 Sep 6;25(9):2038-2052. Impact factor=6.69

Malerba A, Klein P, Bachtarzi H, Jarmin SA, Cordova G, Ferry A, Strings V, Espinoza MP, Mamchaoui K, Blumen SC, St Guily JL, Mouly V, Graham M, Butler-Browne G, Suhy DA, Trollet C, Dickson G. PABPN1 gene therapy for oculopharyngeal muscular dystrophy. Nat Commun. 2017 Mar 31;8:14848. Impact factor=11.32

Ueberschlag-Pitiot V, Stantzou A, Messéant J, Lemaitre M, Owens DJ, Noirez P, Roy P, Agbulut O, Metzger D, Ferry A. Gonad-related factors promote muscle performance gain during postnatal development in male and female mice. Am J Physiol Endocrinol Metab. 2017 Jul 1;313(1):E12-E25. 6. Impact factor = 3.825

Lacour F, Vezin E, Bentzinger CF, Sincennes MC, Giordani L, Ferry A, Mitchell R, Patel K, Rudnicki MA, Chaboissier MC, Chassot AA, Le Grand F. R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways. Cell Rep. 2017 Mar 7;18(10):2320-2330. Impact factor = 7.87

Stantzou  A, Ueberschlag-Pitiot V, Thomasson R, Furling D, Bonnieu A, Amthor H, Ferry A. The effect of constitutive inactivation of the myostatin gene on the gain in muscle strength during postnatal growth in two murine models. Muscle Nerve. 2017 Feb;55(2):254-261. Impact factor=2.28.

Guiraud S, Migeon T, Ferry A, Chen Z, Ouchelouche S, Verpont MC, Sado Y, Allamand V, Ronco P, Plaisier E. HANAC Col4a1 Mutation in Mice Leads to Skeletal Muscle Alterations due to a Primary Vascular Defect. Am J Pathol. 2017 Jan 2. pii: S0002-9440(16)30525-9. Impact factor = 4.2.

Dinulovic I, Furrer R, Beer M, Ferry A, Cardel B, Handschin C. Muscle PGC-1α modulates satellite cell number and proliferation by remodeling the stem cell niche. Skeletal Muscle. 2016 Dec 2;6(1):39. Impact factor = 3.5.

Dinulovic I, Furrer R, Di Fulvio S, Ferry A, Beer M, Handschin C. PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle. Skeletal Muscle. 2016, 6:38. Impact factor = 3.5.

Roy P, Rau F, Ochala J, Messéant J, Fraysse B, Lainé J, Agbulut O, Butler-Browne G, Furling D, Ferry A. Dystrophin restoration therapy improves both the reduced excitability and the force drop induced by lengthening contractions in dystrophic mdx skeletal muscle. Skeletal Muscle 2016, 6 :23 Impact factor = 3.5.

Cattin ME, Ferry A, Vignaud A, Mougenot N, Jacquet A, Wahbi K, Bertrand AT, Bonne G. Mutation in lamin A/C sensitizes the myocardium to exercise-induced mechanical stress but has no effect on skeletal muscles in mouse. Neuromuscul Disord. 2016 Aug;26(8):490-9. Impact factor=2.67.

Ramamoorthy TG, G Laverny, AI Schlagowski, J Zoll, N Messaddeq, JM Bornert, S Panza, A Ferry, B Geny and D Metzger. The transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defense in skeletal muscles. Nat Commun. 2015 Dec 17;6:10210. Impact factor=10.74

Blondelle J, Ohno Y, Gache V, Guyot S, Storck S, Blanchard-Gutton N, Barthélémy I, Walmsley G, Rahier A, Gadin S, Maurer M, Guillaud L, Prola A, Ferry A, Aubin-Houzelstein G, Demarquoy J, Relaix F, Piercy RJ, Blot S, Kihara A, Tiret L, Pilot-Storck F. HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth. Mol Cell Biol. 2015 Oct;7(5):429-40. Impact factor=6.77.

Rau F, Lainé J, Ramanoudjame L, Ferry A, Arandel L, Delalande O, Jollet A, Dingli F, Lee KY, Peccate C, Lorain S, Kabashi E, Athanasopoulos T, Koo T, Loew D, Swanson MS, Le Rumeur E, Dickson G, Allamand V, Marie J, Furling D. Abnormal splicing switch of DMD’s penultimate exon compromises muscle fibre maintenance in myotonic dystrophy. Nat Commun. 2015 May 28;6:7205. Impact factor=10.74

Ferry A, Parlakian A, Joanne P, Fraysse B, Mgrditchian T, Roy P, Furling D, Butler-Browne G, Agbulut O. Mechanical overloading increases maximal force and reduces fragility in hindlimb skeletal muscle from mdx mouse. Am J Pathol. 2015 Jul;185(7):2012-24. Impact factor=5.20

Moinard C, Le Plenier S, Noirez P, Morio B, Bonnefont-Rousselot D, Kharchi C, Ferry A, Neveux N, Cynober L, Raynaud-Simon A. Citrulline Supplementation Induces Changes in Body Composition and Limits Age-Related Metabolic Changes in Healthy Male Rats. J Nutr. 2015 Jul;145(7):1429-37. Impact factor : 4.2

Hénique C., A. Mansouri, V. Lenoir , A. Ferry, C. Esnousa, Ramond E, J. Girard, F. Bouillaud, C. Prip-Buusa, I. Cohen. Increasing Muscle Fatty Acid Oxidation Induces Skeletal Muscle Remodeling Towards An Oxidative Phenotype. FASEB J. 2015 Jun;29(6):2473-83. Impact factor=5.48

Ferry Arnaud, Rachid Benchaouir, Pierre Joanne, Rachel A Peat, Nathalie Mougenot, Onnik Agbulut, Gillian Butler-Browne. Effect of voluntary physical activity initiated at age 7 months on skeletal hindlimb and cardiac muscle function in mdx mice of both sexes. Muscle Nerve. 2015 Nov;52(5):788-94. Impact factor=2.31.

Goyenvalle A, Griffith G, Babbs A, Andaloussi SE, Ezzat K, Avril A, Dugovic B, Chaussenot R, Ferry A, Voit T, Amthor H, Bühr C, Schürch S, Wood MJ, Davies KE, Vaillend C, Leumann C, Garcia L. Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers. Nat Med. 2015 Mar;21(3):270-5. Impact factor=28.05.

Ferry A, Schuh M, Parlakian A, Mgrditchian T, Valnaud N, Joanne P, Butler-Browne G, Agbulut O, Metzger D. Myofiber androgen receptor promotes maximal mechanical overload-induced muscle hypertrophy and fiber type transition in male mice. Endocrinology. 2014 Dec;155(12):4739-48. Impact factor=4.50.

Britto FA, Begue G, Rossano B, Docquier A, Vernus B, Sar C, Ferry A, Bonnieu A, Ollendorff V, Favier FB. REDD1 deletion prevents dexamethasone-induced skeletal muscle atrophy. Am J Physiol Endocrinol Metab. 2014 Dec 1;307(11):E983-93. Impact factor=4.09

Zhenlin Li, Ara Parlakian, Dario Coletti, Sonia Alonso-Martinez, Christophe Hourdé, Pierre Joanne, Jacqueline Gao-Li, Jocelyne Blanc, Arnaud Ferry, Denise Paulin, Zhigang Xue, and Onnik Agbulut. Synemin acts as a regulator of signalling molecules in skeletal muscle hypertrophy. J Cell Sci. 2014 Nov 1;127(21):4589-601. Impact factor=5.3.

Ferry A, Joanne P, Hadj-Said W, Vignaud A, Lilienbaum A, Hourdé C, Medja F, Noirez P, Charbonnier F, Chatonnet A, Chevessier F, Nicole S, Agbulut O, Butler-Browne G. Advances in the understanding of skeletal muscle weakness in murine models of diseases affecting nerve-evoked muscle activity, motor neurons, synapses and myofibers. Neuromuscul Disord. 2014 Nov;24(11):960-72. Impact factor=3.46.

Mouisel Etienne, Karima Relizani, Laurence Mille-Hamard, Raphaël Denis, Christophe Hourde, Onnik Agbulut, Professor Ketan Patel, Ludovic Arandel, Susanne Morales-Gonzalez, Alban Vignaud, Luis Garcia, Arnaud Ferry, Serge Luquet, Veronique Billat, Renee Ventura-Clapier, Markus Schuelke, and Helge Amthor. Myostatin is a key mediator between energy metabolism and endurance capacity of skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2014 Aug 15;307(4):R444-54. Impact factor=3.284.

Relizani Karima, Etienne Mouisel, Christophe Hourdé, Onnik Agbulut, Ketan Patel, Susanne Lützkendorf, Kristina Jülich, Ludovic Arandel, Alban Vignaud, Dominique Fortin, Luis Garcia, Stéphane Blot, Arnaud Ferry, Renée Ventura-Clapier, Markus Schuelke, Helge Amthor. Blockade of ActRIIB signaling triggers muscle fatigability and metabolic myopathy. Mol Ther. 2014 Aug;22(8):1423-33. Impact factor=7.04.

Bodvael Fraysse, Alban Vignaud, Bourama Fane, Mélanie Schuh, Gillian Butler-Browne, Daniel Metzger, Arnaud Ferry. Acute effect of androgens on maximal force-generating capacity and electrically evoked calcium transient in mouse skeletal muscles. Steroids. 2014 May 17;87C:6-11. Impact factor=2.80.

Iori Sakakibara, Marc Santolini, Eddy Perret, Vincent Hakim, Ferry Arnaud, Pascal Maire. Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype. PLoS Genet. 2014 May 22;10(5):e1004386. Impact factor=8.52.

Vassilopoulos S, Gentil C, Lainé J, Buclez PO, Franck A, Ferry A, Précigout G, Roth R, Heuser JE, Brodsky FM, Garcia L, Bonne G, Voit T, Piétri-Rouxel F, Bitoun M. Actin scaffolding by clathrin heavy chain is required for skeletal muscle sarcomere organization. J Cell Biol. 2014 May 12;205(3):377-93. Impact factor=10.82.

Lantier L, Fentz J, Mounier R, Leclerc J, Treebak JT, Pehmøller C, Sanz N, Sakakibara I, Saint-Amand E, Rimbaud S, Maire P, Marette A, Ventura-Clapier R, Ferry A, Wojtaszewski JF, Foretz M, Viollet B. AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity. FASEB J. 2014 Jul;28(7):3211-24. Impact factor=5.70.

Cowling BS, Chevremont T, Prokic I, Kretz C, Ferry A, Coirault C, Koutsopoulos O, Laugel V, Romero NB, Laporte J. Reducing dynamin 2 expression rescues X-linked centronuclear myopathy. J Clin Invest. 2014 Mar 3;124(3):1350-63. Impact factor=14.68.